Endocrine Abstracts

Background: Diabetes mellitus (DM) is the commonest endocrinopathy, Worldwide. Amongst the protean complex genetic variations, cubulin gene and megalin gene mutations in diabetes are important in dictating genotype-phenotypic correlations and natural clinical course of diabetes. The genetic studies in this area are especially very sparse from Indian sub-continent. In this context, we analyzed the prevalence of cubulin (CBN) and megalin (LRP2) gene mutations, as part of NGS (Ne...

Background: Follicular differentiated thyroid cancer (FDTC) is the most common endocrine cancer, globally. Next-generation sequencing (NGS) in thyroid cancer allows for high-throughput genetic sequencing in short time. This analysis offers useful information on tumor biology. NGS Studies on follicular differentiated thyroid cancer are scanty from South East Asia. In this context, we set out study the pattern of a genetic panel wide somatic mutations in thyroid cancer.<p cl...

Background: Thyroid cancers represent a diverse group of malignancies characterized by intricate genomic landscapes, necessitating advanced molecular investigations for a comprehensive understanding of their underlying genetic alterations. This study harnesses the power of Whole Exome Next-Generation Sequencing (WES) to unravel pan-exomic mutations in thyroid cancer samples. The primary objectives include correlating genomic changes with clinicopathologic features and unravell...

Objective: Anaplastic Thyroid Cancer (ATC) represents a formidable challenge in oncology due to its aggressive nature and high metastatic potential. This study delves into the quantitative assessment of microRNAs (miRNAs), specifically miRNA-149-5p, miRNA-548c-3p, and miRNA-3619-3p, to elucidate their roles in ATC progression and metastasis. Employing the robust technique of quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR), we meticulously examine the expr...

Objective: Papillary thyroid carcinoma (PTC) is themalignantcancer with altered microRNA (miR) changes. miR149-5p and miR-548c-3p participates in multiple processes of tumor development, progression, tumor suppression. Whereas miR-3619-3p plays role to promote cell migration and invasion in PTC. However, the role of miR149, miR-548c-3p, and miR-3619-3p in PTC and the underlying mechanisms remain undefined. Therefore, the present study is aimed to quantify therelative expressio...

Background: Preeclampsia (PE) is a multifactorial and multisystem disorder, with unknown pathophysiology, but factors such as defective trophoblast invasion and narrowing of spiral arteries may be contributing to the onset of PE and affecting mother and foetus development. Early prediction of PE may improve the surveillance and prognosis of hypertension in pregnant women in preventing associated complications. Therefore, it is essential to find markers for the detection of PE ...